Natamycin, 95%, Thermo Scientific Chemicals
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Natamycin, 95%, Thermo Scientific Chemicals
Natamycin, 95%, Thermo Scientific Chemicals
Natamycin, 95%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Natamycin, 95%, Thermo Scientific Chemicals

Natamycin (pimaricin, CAS # 7681-93-8) is a polyene macrolide antibiotic with antifungal properties.
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Catalog NumberQuantity
ALFJ66468.MC100 mg
Catalog number ALFJ66468.MC
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Quantity:
100 mg
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Chemical Identifiers
CAS1397-89-3
SpecificationsSpecification SheetSpecification Sheet
HPLC>=80 %
UV spectrumComplies
Water=<10 %
Appearance (Color)Yellow to orange
Appearance (Form)Powder
Pimaricin is an amphoteric antibiotic from Streptomyces chattanoogensis. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics. It is used to study the pleitropic regulator AdpAch and the gamma-butyrolactone regulatory system of Streptomyces chattanoogensis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Natamycin is a member of the macrolide antibiotic class, compounds originally derived from Saccharopolyspora erythraea, a type of soil bacteria

• Natamycin is an amphoteric compound with both acid and basic properties

• Natamycin exhibits antifungal activity • Natamycin exerts its effects by binding sterols within fungal cell walls and increasing membrane permeability, leading to a loss of homeostasis within the cell

Application

• Natamycin is suitable for use in the laboratory study of fungal keratitis and other infections of fungal origin

• Natamycin may also be used in laboratory research of cell physiology and mechanisms of antibiotic resistance

RUO – Research Use Only

General References:

  1. Zhao X, Tong Y, Wang X, Zhang X, Chen S, Lu H. Comparison of the Ocular Penetration and Pharmacokinetics Between Natamycin and Voriconazole After Topical Instillation in Rabbits. J Ocul Pharmacol Ther. 2018 Jul/Aug;34(6):460-467. doi: 10.1089/jop.2017.0139. Epub 2018 May 24. PMID: 29792548.
  2. Guo Y, Karimi F, Fu Q, G Qiao G, Zhang H. Reduced administration frequency for the treatment of fungal keratitis: a sustained natamycin release from a micellar solution. Expert Opin Drug Deliv. 2020 Mar;17(3):407-421. doi: 10.1080/17425247.2020.1719995. Epub 2020 Feb 3. PMID: 32009483.