3-Isobutyl-1-methylxanthine

CAS: 28822-58-4 | C10H14N4O2 | 222.25 g/mol

Catalog Number	Quantity
ALFJ64598.MC	100 mg

Catalog number ALFJ64598.MC

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Quantity:

100 mg

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Chemical Identifiers

CAS71-23-8

IUPAC Namepropan-1-ol

Molecular FormulaC3H8O

InChI KeyBDERNNFJNOPAEC-UHFFFAOYSA-N

SMILESCCCO

Specifications

Appearance (Color)Clear colorless

Infrared spectrumConforms

Acidity=<0.0002 meq/g

Water=<0.05 %

UV1 cm cell vs HPLC-grade water

3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction.

RUO – Research Use Only

General References:

Stephen C. Mann.; Paul A. Andrews.; Stephen B. Howell. Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells. International Journal of Cancer. 1991, 48, (6), 866-872.
Friedman, G.; Chajek-Shaul, T.; Stein, O.; Stein, Y. Modulation of lipoprotein lipase activity in cultured rat mesenchymal heart cells and preadipocytes by dibutyryl cyclic amp, cholera toxin and 3-isobutyl- 1-methylxanthine. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 752, (1), 106-117.