Ampicillin sodium salt, Thermo Scientific Chemicals

Ampicillin sodium salt, CAS # 69-52-3, is the sodium salt form of ampicillin, a semisynthetic derivative of aminopenicillin compound that shows antibacterial activity against both gram-positive and gram-negative bacteria.

Catalog Number	Quantity
ALFJ63807.06	5 g

Catalog number ALFJ63807.06

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Chemical Identifiers

CAS54950-20-8

IUPAC Namemethyl 3-oxo-3-(pyridin-3-yl)propanoate

Molecular FormulaC9H9NO3

InChI KeyJUQKVXRLRKKRPL-UHFFFAOYSA-N

SMILESCOC(=O)CC(=O)C1=CC=CN=C1

Specifications

Appearance (Color)White to yellow to brown

HPLC>=94 %

Appearance (Form)Crystalline powder or crystals and/or chunks

Infrared spectrumConforms

Melting point34°C to 42°C

Ampicillin sodium salt is a reagent for transformed cells expressing beta-lactamase. It acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Ampicillin sodium salt is a semi-synthetic derivative of penicillin with a broad-spectrum antibacterial activity against several species, including Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Ralstonia solanacearum

• It can inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins, inhibiting peptidoglycan synthesis, which is an essential component of the bacterial cell wall

Application

• Ampicillin sodium salt has been used as a reagent for transformed cells that express β-lactamase

• It can be used to select for ampicillin resistance in mutated and transformed cells

• Ampicillin sodium salt acts as a structural analog of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme preventing the cross-linking of the cell wall peptidoglycan, which is necessary for the growth of the bacterium

RUO – Research Use Only

General References:

Hou, X.; Hansen, J. H.; Bjerre, A. B. Integrated bioethanol and protein production from brown seaweed Laminaria digitata. Bioresour. Technol. 2015, 197, 310-317.
Tang, L.; Su, M.; Yan, J.; Xie, S.; Zhang, W. Lid hinge region of Penicillium expansum lipase affects enzyme activity and interfacial activation. Process Biochem. 2015, 50 (8), 1218-1223.