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Fluconazole, 99%, Thermo Scientific Chemicals
Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase.
| Catalog Number | Quantity |
|---|---|
| ALFJ62015.03 | 1 g |
Catalog number ALFJ62015.03
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Quantity:
1 g
Specifications
Chemical Name or MaterialFluconazole
CAS86386-73-4
Health Hazard 1H302-H315-H319-H360D
Health Hazard 2GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Health Hazard 3P201-P202-P264b-P270-P280i-P281-P301+P312-P302+P352-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c
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Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
- It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
- It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
- Mammalian cell demethylation is much less susceptible to fluconazole inhibition
Applications
- Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
- Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
- In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
- It has also been used as a positive control in antifungal assay of plants
RUO – Research Use Only
General References:
- Clancy, C.J.; Yu, V.L.; Morris, A.J.; Snydman, D.R.; Nguyen, M.H. Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia. Antimicrob Agents Chemother. 2005, 49 (8), 3171-3177.
- Matsui, K.; Tsume, Y.; Amidon, G. E.; Amidon, G. L. In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents. Mol. Pharmaceutics. 2015, 12 (7), 2418-2428.
- Bhardwaj, T.; Bhardwaj, V.; Sharma, K.; Gupta, A.; Cameotra, S. S.; Sharma, P. Thermo-acoustical analysis of sodium dodecyl sulfate: Fluconazole (antifungal drug) based micellar system in hydro-ethanol solutions for potential drug topical application. J. Chem. Thermodyn. 2014, 78, 1-6.