Kaempferol, 98+%, Thermo Scientific Chemicals
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Kaempferol, 98+%, Thermo Scientific Chemicals
Kaempferol, 98+%, Thermo Scientific Chemicals
Kaempferol, 98+%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Kaempferol, 98+%, Thermo Scientific Chemicals

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Catalog NumberQuantity
ALFJ60373.MF50 mg
Catalog number ALFJ60373.MF
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Quantity:
50 mg
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Chemical Identifiers
CAS112-24-3
IUPAC Name(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine
Molecular FormulaC6H18N4
InChI KeyVILCJCGEZXAXTO-UHFFFAOYSA-N
SMILESNCCNCCNCCN
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SpecificationsSpecification SheetSpecification Sheet
Color (APHA)≤150
Refractive Index1.4950-1.5010 @20°C
Appearance (Color)Clear colorless to yellow
Assay (GC)≥55.0%
FormLiquid
Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Solubility
Soluble in DMSO or ethanol to 100mM

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Keep away fom strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Montero et al. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem.J. 2004, 384,( Pt 1), 19-24.
  2. Kang et al. () Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 2009, 611 ,( 1-3), 17-21.