alpha-Toluenesulfonyl fluoride, 99%, Thermo Scientific Chemicals

Name: alpha-Toluenesulfonyl fluoride, 99%, Thermo Scientific Chemicals
SKU: ALFB22146.14

CAS: 329-98-6 | C7H7FO2S | 174.189 g/mol

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Catalog number ALFB22146.14

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Chemical Identifiers

CAS81290-20-2

IUPAC Nametert-butyl(trifluoromethyl)silane

Molecular FormulaC5H11F3Si

InChI KeyMTYSDPUZDZURPP-UHFFFAOYSA-N

SMILESCC(C)(C)[SiH2]C(F)(F)F

Specifications

Specification Sheet

Appearance (Color)Clear colorless to pale yellow

FormLiquid

Assay (GC)≥94.0%

Assay by NMR≥94.0% (1H-NMR, CDCl3)

Water Content (Karl Fischer Titration)≤2.50%

α-Toluenesulfonyl fluoride (PMSF) is used in the preparation of cell lysates to inhibit protein digestion. It is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
α-Toluenesulfonyl fluoride (PMSF) is used in the preparation of cell lysates to inhibit protein digestion. It is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.

Solubility
Soluble in ether, benzene, anhydrous ethanol, methanol, 2- propane. Hydrolyses in water.

Notes
Moisture sensitive. Store away from strong oxidizing agents, amines, bases, water/ moisture. Store at 4°C

RUO – Research Use Only

General References:

C Pinsky; A K Dua; F S LaBella. Phenylmethylsulfonyl fluoride (PMSF) given systemically produces naloxone-reversible analgesia and potentiates effects of beta-endorphin given centrally. Life Sciences. 1982, 31 (12-13), 1193-1196.
G T James.Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers. Analytical Biochemistry. 1978, 86 (2), 574-579.