5-Iodouracil, 97%, Thermo Scientific Chemicals

Catalog Number	Quantity
ALFA18994.18	50 g

Catalog number ALFA18994.18

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Chemical Identifiers

CAS819-19-2

IUPAC Namedi-tert-butylphosphane

Molecular FormulaC8H19P

InChI KeyCRHWEIDCXNDTMO-UHFFFAOYSA-N

SMILESCC(C)(C)PC(C)(C)C

Specifications

Appearance (Color)Clear colorless

Titration with HClO40.40 to 0.60 M

NMR (31P-NMR)Consistent with structure

Appearance (Form)Solution

It is used as an intermediate. It has an antitumor activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is used as an intermediate. It has an antitumor activity.

Solubility
Very faint turbidity in NH3aq. Soluble in 1M NaOH.

Notes
Light Sensitive. Store away from oxidizing agents and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

RUO – Research Use Only

General References:

Morris J. Robins.; Philip J. Barr.Nucleic acid related compounds. 31. Smooth and efficient palladium-copper catalyzed coupling of terminal alkynes with 5-iodouracil nucleosides.Tetrahedron Lett.198122(5), 421-424.
MC Willis.; BJ Hicke.; OC Uhlenbeck.; TR Cech.; TH Koch. Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins.Science.1993,262(5137), 1255-1257.
For a review of the use of uracils as starting materials in heterocyclic synthesis, see: Adv. Het. Chem., 55, 130 (1992).