Dansyl chloride, 96%, Thermo Scientific Chemicals

Name: Dansyl chloride, 96%, Thermo Scientific Chemicals
SKU: ALFA13828.14

CAS: 605-65-2 | C12H12ClNO2S | 269.74 g/mol

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Catalog number ALFA13828.14

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Chemical Identifiers

CAS5379-19-1

IUPAC Name1-(2,4-dimethylphenyl)ethan-1-ol

Molecular FormulaC10H14O

InChI KeyDNHQUGRUHBFDFT-UHFFFAOYNA-N

SMILESCC(O)C1=CC=C(C)C=C1C

Specifications

Specification Sheet

Assay (GC)≥94.0%

Appearance (Color)Clear colorless

Refractive Index1.5235-1.5295 @ 20?C

FormLiquid

Dansyl chloride is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Dansyl chloride is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.

Solubility
Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water.

Notes
Store in cool place. Moisture sensitive. Incompatible with strong bases.

RUO – Research Use Only

General References:

Reagent for the preparation of fluorescent derivatives of amino acids and proteins: Biochemistry, 9, 3878 (1970); Anal. Biochem., 53, 132 (1973); 66, 104 (1975).
Lachapelle, A. R.; Solliec, M.; Sauve, S. Determination of BMAA and three alkaloid cyanotoxins in lake water using dansyl chloride derivatization and high-resolution mass spectrometry. Anal. Bioanal. Chem. 2015, 407 (18), 5487-5501.
Karabacak, M.; Cinar, M.; Kurt, M.; Poiyamozhi, A.; Sundaraganesan, N. The spectroscopic (FT-IR, FT-Raman, UV and NMR) first order hyperpolarizability and HOMO-LUMO analysis of dansyl chloride. Spectrochim. Acta, Part A 2014, 117, 234-244.