5-Fluorouracil, 99%, Thermo Scientific Chemicals

Name: 5-Fluorouracil, 99%, Thermo Scientific Chemicals
SKU: ALFA13456.22

CAS: 51-21-8 | C4H3FN2O2 | 130.08 g/mol

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Catalog number ALFA13456.22

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Chemical Identifiers

CAS110-27-0

IUPAC Namepropan-2-yl tetradecanoate

Molecular FormulaC17H34O2

InChI KeyAXISYYRBXTVTFY-UHFFFAOYSA-N

SMILESCCCCCCCCCCCCCC(=O)OC(C)C

Specifications

Specification Sheet

Color scale=<30 APHA

Water=<0.1 %

Refractive index1.4340 to 1.4360 (20°C, 589 nm)

Iodine value=<1 g I2/100 g

Appearance (Form)Clear liquid

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.

Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

RUO – Research Use Only

General References:

Antineoplastic agent. Not for drug use.
Cosco, D.; Paolino, D.; Maiuolo, J.; Di Marzio, L.; Carafa, M.; Ventura, C. A.; Fresta, M. Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. Int. J. Pharm. 2015, 489 (1-2), 1-10.
Wu, X.; He, C.; Wu, Y.; Chen, X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials 2016, 75, 148-162.