Fumonisin B1, 96%, Thermo Scientific Chemicals

Name: Fumonisin B1, 96%, Thermo Scientific Chemicals
SKU: ACR328250010

Fumonisin, CAS # 116355-83-0, also known as Macrofusine, is a cell permeable mycotoxin that is an inhibitor of sphingosine N-acetyl transferase.

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Chemical Identifiers

CAS543-49-7

IUPAC Nameheptan-2-ol

Molecular FormulaC7H16O

InChI KeyCETWDUZRCINIHU-UHFFFAOYNA-N

SMILESCCCCCC(C)O

Specifications

Specification Sheet

Appearance (Color)Clear colorless

GC>=99.0 %

Specific gravity(20°C) 0.816 to 0.819

Appearance (Form)Liquid

Refractive index1.4200 to 1.4220 (20°C, 589 nm)

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fumonisin is a fungal metabolite that is a cell permeable mycotoxin that can halt sphingolipid biosynthesis by inhibiting sphingosine N-acetyl transferase

Applications

• It can potently inhibit sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases

• It is also a protein serine and threonine phosphatase inhibitor

• It can selectively inhibit sphingomyelin biosynthesis in neuronal cells

RUO – Research Use Only

General References:

Stockmann-Juvala, H., et al., 2008. A review of the toxic effects and mechanisms of action of fumonisin B1. Human & experimental toxicology. 27(11), 799-809.
Fukuda et al (1996) Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin. Biochem.Biophys.Res.Comms. 220 160.