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Lovastatin, 98%
Lovastatin, CAS # 75330-75-5, is a cholesterol lowering compound and inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis.
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Catalog number FSA458830050
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Quantity:
5 g
Specifications
Chemical Name or MaterialLovastatin
CAS75330-75-5
Health Hazard 1GHS Signal Word: Warning
Health Hazard 2GHS H Statement
May cause an allergic skin reaction.
Suspected of causing cancer.
Suspected of damaging the unborn child.
May cause an allergic skin reaction.
Suspected of causing cancer.
Suspected of damaging the unborn child.
Health Hazard 3GHS P Statement
Wear protective gloves/protective clothing.
IF ON SKIN: Wash with plenty of soap and water.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.
Wear protective gloves/protective clothing.
IF ON SKIN: Wash with plenty of soap and water.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Applications
• It blocks product ion of mevalonate, a critical compound in the production of cholesterol and isoprenoids
• It can increase cellular resistance to anticancer agents such as doxorubicin • It can induce apoptosis in myeloma cells
• It can cause cell cycle arrest in G1 and G2/M phase
• It also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF
RUO – Research Use Only
General References:
- Tobert, A.J. Efficacy and long-term adverse effect pattern of lovastatin. The American Journal of Cardiology. 1988, 62, (15),J28-J34.
- Jones, P. MD; Kafonek, S. MD; Laurora, I. PharmD; Donald Hunninghake MD. Comparative Dose Efficacy Study of Atorvastatin VersusSimvastatin, Pravastatin, Lovastatin, and Fluvastatin in Patients With Hypercholesterolemia (The CURVES Study). The American Journal of Cardiology. 1998, 81, (5),582-587.