Fluconazole, 98%

Name: Fluconazole, 98%
SKU: FSA455480010

Fluconazole, 98%, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase.

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5 g

Catalog number FSA455480010

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Chemical Identifiers

CAS101-61-1

IUPAC Name4-{[4-(dimethylamino)phenyl]methyl}-N,N-dimethylaniline

Molecular FormulaC17H22N2

InChI KeyJNRLEMMIVRBKJE-UHFFFAOYSA-N

SMILESCN(C)C1=CC=C(CC2=CC=C(C=C2)N(C)C)C=C1

Specifications

Specification Sheet

Appearance (Color)White to cream or brown or blue to purple to gray

Assay (GC)≥98.0%

FormCrystals or powder or crystalline powder or fused solid or flakes

Melting Point (clear melt)84.0-90.0°C

Identification (FTIR)Conforms

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species

• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity

• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)

• Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.

• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene

• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays

• It has also been used as a positive control in antifungal assay of plants

RUO – Research Use Only

General References:

Clancy, C.J.; Yu, V.L.; Morris, A.J.; Snydman, D.R.; Nguyen, M.H. Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia. Antimicrob Agents Chemother. 2005, 49 (8), 3171-3177.
Matsui, K.; Tsume, Y.; Amidon, G. E.; Amidon, G. L. In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents. Mol. Pharmaceutics. 2015, 12 (7), 2418-2428.
Bhardwaj, T.; Bhardwaj, V.; Sharma, K.; Gupta, A.; Cameotra, S. S.; Sharma, P. Thermo-acoustical analysis of sodium dodecyl sulfate: Fluconazole (antifungal drug) based micellar system in hydro-ethanol solutions for potential drug topical application. J. Chem. Thermodyn. 2014, 78, 1-6.