G418 sulfate, for biochemistry

Name: G418 sulfate, for biochemistry
SKU: FSA329400010

G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic.

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Quantity:

1 g

Packaging:

Glass Bottle

Catalog number FSA329400010

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Quantity:

1 g

Packaging:

Glass Bottle

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Specifications

Chemical Name or MaterialG418 sulfate

TypeG418 Sulfate

Physical FormPowder

CAS108321-42-2

Health Hazard 2GHS H Statement:
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause an allergic skin reaction.
May damage fertility. May damage the unborn child.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis

Applications

• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry

RUO – Research Use Only

General References:

Arshad, H.; Patel, Z.; Mehrabian, M.; Bourkas, M.; Al-Azzawi, Z.; Schmitt-Ulms, G., & Watts, J. C. 2021. The aminoglycoside G418 hinders de novo prion infection in cultured cells. The Journal of biological chemistry, 297(3), 101073.
Ferguson, M. W.; Gerak, C.; Chow, C.; Rastelli, E. J.; Elmore, K. E.; Stahl, F.; Hosseini-Farahabadi, S.; Baradaran-Heravi, A.; Coltart, D. M., & Roberge, M. 2019. The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. PloS one, 14(5), e0216423.