Fumonisin B2, 96+%
Element SearchElement SearchStructure SearchStructure Search
Fumonisin B2, 96+%
Fumonisin B2, 96+%
Fumonisin B2, 96+%
Thermo Scientific Chemicals

Fumonisin B2, 96+%

Fumonisin B2, CAS # 116355-84-1, is a diester of tricarballylic acid and is isolated from Fusarium. | CAS: 116355-84-1 | C34H59NO14·3H2O | 759.9 g/mol
Have Questions?
Catalog NumberQuantity
FSA3282600101 mg
Catalog number FSA328260010
View Price:Sign in to see your account pricing. Need an account? Register with us today.
Quantity:
1 mg
Request bulk or custom format
Chemical Identifiers
CAS19381-50-1
IUPAC Nametrisodium tris(6-hydroxy-5-nitrosonaphthalene-2-sulfonate) iron
Molecular FormulaC30H18FeN3Na3O15S3
InChI KeyVLBLPLXOYXEXJK-UHFFFAOYSA-K
SMILES[Na+].[Na+].[Na+].[Fe].OC1=C(N=O)C2=CC=C(C=C2C=C1)S([O-])(=O)=O.OC1=C(N=O)C2=CC=C(C=C2C=C1)S([O-])(=O)=O.OC1=C(N=O)C2=CC=C(C=C2C=C1)S([O-])(=O)=O
View more
SpecificationsSpecification SheetSpecification Sheet
Identification (FTIR)Conforms
FormCrystals or powder or crystalline powder
Appearance (Color)Dark green to black
UV/VisConforms
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Fumonisin B2 is a fumonisin mycotoxin produced by the fungus Fusarium
  • Fumonisin B2 is a structural analog of fumonisin B1 but it is more cytotoxic than B1 and can inhibit sphinganine-N-acetyltransferase (ceramide synthase)

Applications

  • In vitro and in vivo studies have shown Fumonisin B2 can induce apoptosis
  • It can inhibit de novo sphingolipid biosynthesis
  • It is also considered an Aspergillus metabolite
  • It shows cytotoxicity against a panel of seven rat hepatoma cell lines, and MDCK cell line
  • It induces hepatocyte nodule formation, a marker of cancer initiation, in rats
RUO – Research Use Only

General References:

  1. Gelderblom, W.C.A.; Jaskiewicz, K.; Marasas, W.F.O., et al. Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 1988, 54, (7), 1806-1811.
  2. Shier, W.T.; Abbas, H.K.; and Mirocha, C.J. Toxicity of the mycotoxins fumonisins B1 and B2 and Alternaria alternata f. sp. lycopersici toxin (AAL) in cultured mammalian cells. Mycopathologia. 1991, 116, (2), 97-104.
  3. Gelderblom, W.C.A.; Cawood, M.E., Snyman, S.D., et al. Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assays. Food Chem. Toxicol. 1993, 31, (6), 407-414.