Bafilomycin A1, 95%
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Bafilomycin A1, 95%
Bafilomycin A1, 95%
Bafilomycin A1, 95%
Thermo Scientific Chemicals

Bafilomycin A1, 95%

Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity. | CAS: 88899-55-2 | C35H58O9 | 622.84 g/mol
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Catalog NumberQuantity
FSA3281200010.1 mg
Catalog number FSA328120001
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0.1 mg
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Chemical Identifiers
CAS1313-60-6
IUPAC Namedisodium dioxidanediide
Molecular FormulaNa2O2
InChI KeyPFUVRDFDKPNGAV-UHFFFAOYSA-N
SMILES[Na+].[Na+].[O-][O-]
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SpecificationsSpecification SheetSpecification Sheet
AppearanceMay contain a small quantity of discolored
Phosphate (PO4)=<5 ppm
Titration with KMnO4>=93.0 %
Heavy metals (as Pb)=<20 ppm
Sulfate (SO4)=<10 ppm
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
  • It is a macrolide antibiotic, and shows fungicide activity

Application

  • Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
  • It can be immunosuppressive
  • It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
  • It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)
RUO – Research Use Only

General References:

  1. Miao, Y.; Li, G.; Zhang, X.; Xu, H.; Abraham, S. N. A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell. 2015, 161 (6), 1306-1319.
  2. Lee, K. I.; Kim, M. J.; Koh, H.; Lee, J. I.; Namkoong, S.; Oh, W. K.; Park, J.The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux. Biochem. Biophys. Res. Commun. 2015, 462 (4), 402-408.