D-Cycloserine, 98%

Name: D-Cycloserine, 98%
SKU: FSA228480010

D-Cycloserine, CAS # 68-41-7, is a cyclic amino acid analog of D-alanine, originally isolated from Streptomyces species. It is synthetically formulated and exhibits antibiotic properties through its inhibition of bacterial cell wall synthesis.

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Glass bottle

Catalog number FSA228480010

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Chemical Identifiers

CAS7789-69-7

IUPAC Namepentabromo-λ⁵-phosphane

Molecular FormulaBr5P

InChI KeyQRKVRHZNLKTPGF-UHFFFAOYSA-N

SMILESBrP(Br)(Br)(Br)Br

Specifications

Specification Sheet

Appearance (Color)Yellow to orange

FormCrystalline powder and/or Lumps

Assay (Titration ex Bromide)>94.0 to <106.0%

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

D-Cycloserine was originally isolated from Streptomyces orchidaceus and is currently formulated as an oral antibiotic
It is incompatible with strong oxidizing agents but stable under basic conditions, with the greatest stability at pH = 11.5
D-Cycloserine inhibits L-alanine racemase and D-alanine:D-alanine ligase, 2 enzymes responsible for bacterial cell wall synthesis
When ingested, D-Cycloserine traverses the blood-brain barrier, potentially causing neurological side effects such as, dizziness, nausea, depression, tremors, etc.

Applications

D-Cycloserine is a broad-spectrum antibiotic used as a second line agent for treatment of drug-resistant tuberculosis, always in combination with other antituberculosis agents
It is an excitatory amino acid and partial agonist of the NMDA receptor in the central nervous system (CNS), thus playing a potential role in the amelioration of neuropathic pain
D-Cycloserine has also been shown to play a role in neural connectivity, and is therefore used to study treatment applications in anxiety disorders and schizophrenia

RUO – Research Use Only