L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
Element SearchElement SearchStructure SearchStructure Search
L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity.
Have Questions?
Change viewbuttonViewtableView
Quantity:
100 mg
25 mg
Packaging:
Glass Bottle
Catalog number FSA208101000
View Price:Sign in to see your account pricing. Need an account? Register with us today.
Quantity:
100 mg
Packaging:
Glass Bottle
Request bulk or custom format
Chemical Identifiers
CAS389-08-2
IUPAC Name1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Molecular FormulaC12H12N2O3
InChI KeyMHWLWQUZZRMNGJ-UHFFFAOYSA-N
SMILESCCN1C=C(C(O)=O)C(=O)C2=CC=C(C)N=C12
View more
SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to light yellow
Titration with NaOH>=99.4 %
Appearance (Form)Powder
Melting point225°C to 231°C
Infrared spectrumConforms
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
  • It has tumoricidal activity

Applications

  • L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
  • It can be used in anti-tumor studies
  • It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
  • It can also inhibit production of pro-inflammatory cytokines
RUO – Research Use Only

General References:

  1. Friedman, B.; Cronstein, B. Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine. 2019, 86(3), 301-307.
  2. Sasso, S.P.; Gilli, R.M.; Sari, J.C.; Rimet, O.S.; Briand, C.M. Thermodynamic study of dihydrofolate reductase inhibitor selectivity. Biochim Biophys Acta. 1994, 20, 1207(1), 74-9.
  3. Pittman, S.M.; Strickland, D.; Ireland, C.M. Polymerization of tubulin in apoptotic cells is not cell cycle dependent. Exp Cell Res. 1994, 215 (2), 263-72.