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Vitamin D3, ≥99%
Vitamin D3, 99%, CAS # 67-97-0, also known as cholecalciferol, is a steroid hormone produced in the skin or obtained from dietary sources. It is an essential mediator of bone calcium metabolism.
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Catalog number FSA140940050
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Quantity:
5 g
Packaging:
Glass bottle
Specifications
Chemical Name or MaterialVitamin D3
CAS67-97-0
Health Hazard 1Danger
Health Hazard 2GHS H Statement:
Toxic in contact with skin.
Causes damage to organs through prolonged or repeated exposure.
Fatal if inhaled.
Toxic if swallowed.
Toxic in contact with skin.
Causes damage to organs through prolonged or repeated exposure.
Fatal if inhaled.
Toxic if swallowed.
Health Hazard 3GHS P Statement:
Wear protective gloves/protective clothing/eye protection/face protection.
Do not breathe dust/fume/gas/mist/vapors/spray.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN: Gently wash with plenty of soap and water.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
Wear protective gloves/protective clothing/eye protection/face protection.
Do not breathe dust/fume/gas/mist/vapors/spray.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN: Gently wash with plenty of soap and water.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Vitamin D3 is a steroid hormone generated in the skin when the 7-dehydrocholesterol interacts with ultraviolet irradiation. It can also be found in several types of food for daily intake.
• Vitamin D3 binds to vitamin D receptors, thus modulating gene expression
Applications
• In in vivo studies, vitamin D3 has been implicated in the maintenance of blood calcium and phosphorus levels, bone metabolism, metabolic functions, and transcription regulation
• It modulates the proliferation and differentiation of both normal and cancer cells
• It presents in vitro antiproliferative and antimetastatic activities on breast, colon, and prostate cancer cells
RUO – Research Use Only
General References:
- Chakraborti, C. K. Vitamin D as a promising anticancer agent. Indian J Pharmacol. 2011 Apr;43(2):113-20. doi: 10.4103/0253-7613.77335.
- Meyer, O.; Dawson-Hughes, B.; Sidelnikov, E.; Egli, A.; Grob, D.; Staehelin, H. B.; Theiler, G.; Kressig, R. W.; Simmen, H. P.; Theiler, R.; Bischoff-Ferrari, H. A. Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial. Osteoporos Int. 2015, 26 (1), 373-381.
- Mehlig, L. M.; Garve, C.; Tauer, J. T.; Suttorp, M.; Bauer, A. Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes. Mol. Med. Rep. 2015, 11 (4), 3143-3147.