Methotrexate disodium salt, 98.5%
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Methotrexate disodium salt, 98.5%
Methotrexate disodium salt, 98.5%
Methotrexate disodium salt, 98.5%
Thermo Scientific Chemicals

Methotrexate disodium salt, 98.5%

Methotrexate disodium salt, CAS # 7413-34-5, is the sodium salt of methotrexate that shows antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities. | CAS: 7413-34-5 | C20H20N8Na2O5 | 498.411 g/mol
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Catalog NumberQuantity
ALFJ66364.MD250 mg
Catalog number ALFJ66364.MD
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250 mg
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Specifications
Chemical Name or MaterialMethotrexate disodium salt
CAS7413-34-5
Health Hazard 1H301-H315-H319
Health Hazard 2GHS H Statement
H301
Toxic if swallowed.
Health Hazard 3P264b-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c
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Inhibits the metabolism of folic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Methotrexate disodium salt is an organic sodium salt derived from methotrexate with antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities

• It acts as an enzyme inhibitor of dihydrofolate reductase

• It binds to and inhibits purine nucleotide and thymidylate synthesis, leading to the inhibition of DNA and RNA synthesis. Because of this mechanism of action, the methotrexate disodium salt is defined as a nucleic acid synthesis inhibitor

Application

• Methotrexate disodium salt is a folic acid antagonist with the ability to inhibit folic acid metabolism

• In vitro studies demonstrated that methotrexate disodium salt has potent activity against pyrimethamine-resistant Plasmodium vivax malaria parasites

• This compound has been used in chimeric polymersomes in order to investigate its effect in lung tumor xenografts in mice

RUO – Research Use Only

General References:

  1. Benedek, T. Methotrexate: from its introduction to non-oncologic therapeutics to anti-TNF-α. Clin Exp Rheumatol. 2010, 28 (5 Suppl 61), S3-8. Johnston, A.; Gudjonsson, J.; Sigmundsdottir, H.; Ludviksson, B.; Valdimarsson, H. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin Immunol. 2005, 114 (2), 154-163.
  2. Burmester, G.; Pope, J. Novel treatment strategies in rheumatoid arthritis. Lancet. 2017, 10, 389 (10086), 2338-2348. Yang W, Zou Y, Meng F, Zhang J, Cheng R, Deng C, Zhong Z. Efficient and Targeted Suppression of Human Lung Tumor Xenografts in Mice with Methotrexate Sodium Encapsulated in All-Function-in-One Chimeric Polymersomes. Adv Mater. 2016, 28, (37), 8234-8239.