Domperidone, Thermo Scientific Chemicals

Name: Domperidone, Thermo Scientific Chemicals
SKU: ALFJ63681.MC

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier

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Catalog number ALFJ63681.MC

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Chemical Identifiers

CAS78-80-8

IUPAC Name2-methylbut-1-en-3-yne

Molecular FormulaC5H6

InChI KeyBOFLDKIFLIFLJA-UHFFFAOYSA-N

SMILESCC(=C)C#C

Specifications

Specification Sheet

Assay (GC)≥96.0%

Refractive Index1.4155-1.4215 @ 20?C

Appearance (Color)Clear colorless to yellow

Identification (FTIR)Conforms

FormLiquid

Domperidone is used as a Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier. The antidopaminergic effects of Domperidone have been correlated to antiemetic and gastroprokinetic action.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Domperidone is used as a Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier. The antidopaminergic effects of Domperidone have been correlated to antiemetic and gastroprokinetic action.

Solubility
Slightly soluble in water.

Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

RUO – Research Use Only

General References:

Pierre M. Laduron.; Josee E. Leysen. Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity. Biochemical Pharmacology. 1979, 28, (14), 2161-2165.
Jai D. Kohli.; Dana Glock.; Leon I. Goldberg. Selective DA2 versus DA1 antagonist activity of domperidone in the periphery. European Journal of Pharmacology. 1983, 89, (1-2), 137-141.