Tamoxifen, 98%, Thermo Scientific Chemicals
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Tamoxifen, 98%, Thermo Scientific Chemicals
Tamoxifen, 98%, Thermo Scientific Chemicals
Tamoxifen, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Tamoxifen, 98%, Thermo Scientific Chemicals

Tamoxifen (citofen, CAS # 10540-29-1) is an antineoplastic agent that has its effect through the estrogen receptors.
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Quantity:
500 mg
1 g
Catalog number ALFJ63509.ME
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Quantity:
500 mg
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Chemical Identifiers
CAS629-96-9
IUPAC Nameicosan-1-ol
Molecular FormulaC20H42O
InChI KeyBTFJIXJJCSYFAL-UHFFFAOYSA-N
SMILESCCCCCCCCCCCCCCCCCCCCO
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SpecificationsSpecification SheetSpecification Sheet
Infrared spectrumConforms
GC>=97.5 %
Appearance (Form)Powder or pellets and/or chunks
Appearance (Color)White
Melting point62°C to 66°C
Inhibitor of protein kinase C and induces apoptosis in cancer cells. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Tamoxifen is a tertiary aminobenzene that acts by competitively binding and antagonizing estrogen receptors to reduce DNA synthesis
  • When estradiol cannot bind estrogen receptors, the DNA response element is not activated
  • Tamoxifen upregulates the production of TGFb and slows tumor growth
  • Tamoxifen inhibits the production of IGF-1, a stimulator of tumor growth

Application

  • Tamoxifen may be useful in the study of tumorigenesis, growth, and inflammation
  • It is suitable for in vitro experiments
RUO – Research Use Only

General References:

  1. Mikelman, S.; Guptaroy, B.; Jutkiewicz, E.; Gnegy, M. The Protein Kinase C Inhibitor Tamoxifen Inhibits Neurochemical and Reinforcing Behavioral Effects of Amphetamine. FASEB J. 2015, 29 (1), 930-1011.
  2. Chlebowski, R. T. IBIS-I tamoxifen update: maturity brings questions. Lancet Oncol. 2015, 16 (1), 7-9.