1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals
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1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals
1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals
1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals
Thermo Scientific Chemicals

1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals

1,1-Dimethylbiguanide hydrochloride (metformin hydrochloride, CAS # 115-70-4) is the salt of methylated biguanide, a compound exhibiting anti-hyperglycemic properties.
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Catalog number ALFJ63361.06
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Chemical Identifiers
CAS7772-98-7
IUPAC Namedisodium sulfanidesulfonate
Molecular FormulaNa2O3S2
InChI KeyAKHNMLFCWUSKQB-UHFFFAOYSA-L
SMILES[Na+].[Na+].[O-]S([S-])(=O)=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Form)Crystalline powder
Loss on drying=<1 % (105°C)
Chloride (Cl)=<0.05 %
Calcium (Ca)=<50 ppm
Iron (Fe)=<50 ppm
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1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

RUO – Research Use Only

General References:

  1. Matthews DR, Paldánius PM, Proot P, Chiang Y, Stumvoll M, Del Prato S; VERIFY study group. Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial. Lancet. 2019 Oct 26;394(10208):1519-1529. doi: 10.1016/S0140-6736(19)32131-2. Epub 2019 Sep 18. PMID: 31542292.
  2. Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature. 2019 Apr;568(7751):254-258. doi: 10.1038/s41586-019-1005-x. Epub 2019 Mar 6. PMID: 30842661; PMCID: PMC6698916.