Search Thermo Fisher Scientific
Element Search
Structure Search
Thermo Scientific Chemicals
Cephalexin hydrate, 97+%, Thermo Scientific Chemicals
Cephalexin hydrate, cefalexin hydrate, CAS # 23325-78-2, is a first-generation cephalosporin antibiotic from the beta-lactam family.
| Catalog Number | Quantity |
|---|---|
| ALFJ63172.06 | 5 g |
Catalog number ALFJ63172.06
Price (MYR)
614.00
Quantity:
5 g
Price (MYR)
614.00
Specifications
Chemical Name or MaterialCephalexin hydrate
TypeCephalexin Hydrate
Physical FormPowder
CAS15686-71-2
Health Hazard 1Respiratory sensitisation (category 1), Skin sensitisation (category 1)
View more
Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis. Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Cephalexin hydrate is the hydrate of the cephalosporin antibiotic, cephalexin
• Cephalexin is a beta-lactam antibiotic that inhibits bacterial growth and division
• Cephalexin binds to penicillin-binding protein and inhibits cell wall synthesis
Application
• Cephalexin works best on gram-positive microbes
• Useful for immunology research, particularly on antibiotic allergies and cross-reactivity
RUO – Research Use Only
General References:
- Salatin S, Lotfipour F, Jelvehgari M. Preparation and characterization of a novel thermosensitive and bioadhesive cephalexin nanohydrogel: a promising platform for topical antibacterial delivery. Expert Opin Drug Deliv. 2020 Jun;17(6):881-893. doi: 10.1080/17425247.2020.1764530. Epub 2020 May 22. PMID: 32441175.
- Gwee A, Autmizguine J, Curtis N, Duffull SB. Twice- and Thrice-daily Cephalexin Dosing for Staphylococcus aureus Infections in Children. Pediatr Infect Dis J. 2020 Jun;39(6):519-522. doi: 10.1097/INF.0000000000002646. PMID: 32412727.