Cimetidine, 98+%, Thermo Scientific Chemicals

H2 histamine receptor antagonist

Catalog Number	Quantity
ALFJ62825.06	5 g

Catalog number ALFJ62825.06

View Price:

Quantity:

Request bulk or custom format

Chemical Identifiers

CAS540-84-1

IUPAC Name2,2,4-trimethylpentane

Molecular FormulaC8H18

InChI KeyNHTMVDHEPJAVLT-UHFFFAOYSA-N

SMILESCC(C)CC(C)(C)C

Specifications

Color scale=<10 APHA

GC/ECD (as lindane)=<5 ng/l

GC>=99.5 %

Acidity (CH3COOH)=<0.003 %

Appearance (Form)Clear liquid

Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand. It displays antitumor and immunomodulatory activity. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent and is an activator of Nischarin. Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble to 50 mM in water and to 100 mM in DMSO, solubility in HCl (almost transparency).

Notes
Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

RUO – Research Use Only

General References:

Yasui-Furukori N, et al. Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.Clinical pharmacology and therapeutics.,2005,77(1), 17-23.
Yoshizawa F, et al. Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats.Journal of clinical pharmacology.,1981,21(2), 87-91.