Nifedipine, 98%, Thermo Scientific Chemicals
Nifedipine, 98%, Thermo Scientific Chemicals
Nifedipine, 98%, Thermo Scientific Chemicals
Nifedipine, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Nifedipine, 98%, Thermo Scientific Chemicals

L-type calcium channel blocker; induces apoptosis in human glioblastoma cells
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Catalog NumberQuantity
ALFJ62811.1425 g
Catalog number ALFJ62811.14
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Quantity:
25 g
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Specifications
Chemical Name or MaterialNifedipine
CAS21829-25-4
Health Hazard 1H302
Health Hazard 2GHS H Statement
H302
Harmful if swallowed.
Health Hazard 3P264b-P270-P301+P312-P330-P501c
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L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.

Solubility
Soluble in acetone, methylene chloride, chloroform, ethyl acetate, dimethyl sulfoxide and methanol. Sparingly soluble in ethanol. Insoluble in water.

Notes
Light sensitive. Store in a cool place. Incompatible with strong acids, strong oxidizing agents, caustics, aliphatic amines, amides, diethylamine, potassium hydride and potassium hydroxide.
RUO – Research Use Only

General References:

  1. Weerapol, Y.; Limmatvapirat, S.; Jansakul, C.; Takeuchi, H.; Sriamornsak, P. Enhanced dissolution and oral bioavailability of nifedipine by spontaneous emulsifying powders: Effect of solid carriers and dietary state. Eur. J. Pharm. Biopharm. 2015, 91, 25-34.
  2. Miao, X. N.; Siu, K. L.; Cai, H. Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications. J. Mol. Cell. Cardiol. 2015, 87, 152-159.