Thimerosal, Thermo Scientific Chemicals
Element SearchElement SearchStructure SearchStructure Search
Thimerosal, Thermo Scientific Chemicals
Thimerosal, Thermo Scientific Chemicals
Thimerosal, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Thimerosal, Thermo Scientific Chemicals

Thimerosal, CAS # 54-64-8, is a sulfhydryl (thiol) oxidizing reagent with antibacterial and antifungal activities that is used to protect components from chemical change or microbial action.
Have Questions?
Change viewbuttonViewtableView
Quantity:
25 g
10 g
Catalog number ALFJ61799.14
View Price:Sign in to see your account pricing. Need an account? Register with us today.
Quantity:
25 g
Request bulk or custom format
Chemical Identifiers
CAS2892-62-8
IUPAC Namedibutoxycyclobut-3-ene-1,2-dione
Molecular FormulaC12H18O4
InChI KeyXBRWELTXMQSEIN-UHFFFAOYSA-N
SMILESCCCCOC1=C(OCCCC)C(=O)C1=O
View more
SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)Clear colorless to yellow
Refractive Index1.4930-1.4970 @ 20?C
FormLiquid
Assay (GC)≥97.5%
Thimerosal, has been widely used as a preservative in a number of biological and drug products, including many vaccines, to help prevent potentially life threatening contamination with harmful microbes. It has been used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Thimerosal is an organic compound and a derivative of thiosalicyclic acid. It shows antibacterial and antifungal activities and has the ability to protect against chemical change or microbial action

• Thimerosal can inhibit the sulfhydryl-containing active site of some enzymes and bind to sulfhydryl compounds, such as glutathione, cysteine, and thiol groups of proteins

• It can activate the InsP3 calcium channel on the endoplasmic reticular membrane, triggering the release of calcium from intracellular stores, leading to a calcium-influx of extracellular calcium. Thus, thimerosal may stimulate or inhibit cellular functions dependent on calcium signaling

Application

• Thimerosal can increase histamine release and cell-mediated immunity

• It has the ability to inhibit various sulfhydryl-dependent enzymes and proteins, including PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na+/K+-dependent ATPases

RUO – Research Use Only

General References:

  1. A Hviid.; M Stellfeld.; J Wohlfahrt.; M Melbye. Association between thimerosal-containing vaccine and autism. JAMA. 2003, 290, (13), 1763-1766. Elferink JG. Thimerosal: a versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent. Gen Pharmacol. 1999, 33, (1), 1-6.
  2. Li WX, Chen SF, Chen LP, Yang GY, Li JT, Liu HZ, Zhu W. Thimerosal-induced apoptosis in mouse C2C12 myoblast cells occurs through suppression of the PI3K/Akt/survivin pathway. PLoS One. 2012, 7, (11), e49064.