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Thimerosal, Thermo Scientific Chemicals
Thimerosal, CAS # 54-64-8, is a sulfhydryl (thiol) oxidizing reagent with antibacterial and antifungal activities that is used to protect components from chemical change or microbial action.
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Catalog number ALFJ61799.09
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Quantity:
10 g
Specifications
Chemical Name or MaterialThimerosal
CAS54-64-8
Health Hazard 1H300+H310+H330-H373
Health Hazard 2GHS H Statement
H301-H310-H330-H373
Toxic if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
May cause damage to organs through prolonged or repeated exposure.
H301-H310-H330-H373
Toxic if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
May cause damage to organs through prolonged or repeated exposure.
Health Hazard 3P260-P262-P264b-P270-P271-P280-P284-P301+P310-P302+P350-P304+P340-P310-P312-P314-P330-P361-P363-P501c
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Thimerosal, has been widely used as a preservative in a number of biological and drug products, including many vaccines, to help prevent potentially life threatening contamination with harmful microbes. It has been used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Thimerosal is an organic compound and a derivative of thiosalicyclic acid. It shows antibacterial and antifungal activities and has the ability to protect against chemical change or microbial action
• Thimerosal can inhibit the sulfhydryl-containing active site of some enzymes and bind to sulfhydryl compounds, such as glutathione, cysteine, and thiol groups of proteins
• It can activate the InsP3 calcium channel on the endoplasmic reticular membrane, triggering the release of calcium from intracellular stores, leading to a calcium-influx of extracellular calcium. Thus, thimerosal may stimulate or inhibit cellular functions dependent on calcium signaling
Application
• Thimerosal can increase histamine release and cell-mediated immunity
• It has the ability to inhibit various sulfhydryl-dependent enzymes and proteins, including PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na+/K+-dependent ATPases
RUO – Research Use Only
General References:
- A Hviid.; M Stellfeld.; J Wohlfahrt.; M Melbye. Association between thimerosal-containing vaccine and autism. JAMA. 2003, 290, (13), 1763-1766. Elferink JG. Thimerosal: a versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent. Gen Pharmacol. 1999, 33, (1), 1-6.
- Li WX, Chen SF, Chen LP, Yang GY, Li JT, Liu HZ, Zhu W. Thimerosal-induced apoptosis in mouse C2C12 myoblast cells occurs through suppression of the PI3K/Akt/survivin pathway. PLoS One. 2012, 7, (11), e49064.