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Tacrine hydrochloride
A potent centrally acting anticholinesterase | CAS: 1684-40-8 | C13H15ClN2 | 234.73 g/mol
| Catalog Number | Quantity |
|---|---|
| ALFJ60070.06 | 5 g |
Catalog number ALFJ60070.06
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Quantity:
5 g
Specifications
Chemical Name or MaterialTacrine hydrochloride
CAS1684-40-8
Health Hazard 1H302+H332-H315-H319-H335
Health Hazard 2GHS H Statement
H331-H302-H315-H319-H335
Toxic if inhaled.
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
H331-H302-H315-H319-H335
Toxic if inhaled.
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Health Hazard 3P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
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A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in aqueous buffers
Notes
Refrigerate. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
Soluble in aqueous buffers
Notes
Refrigerate. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
RUO – Research Use Only
General References:
- Shuai Qian; Lisi He; Marvin Mak; Yifan Han; Chun-Yu Ho; Zhong Zuo. Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors. International Journal of Pharmaceutics, 2014, 477(1-2), 442-453.
- Jinggong Liu et. al. Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - General Subjects, 2006,1840(9).