alpha-Toluenesulfonyl fluoride, 99%, Thermo Scientific Chemicals

Name: alpha-Toluenesulfonyl fluoride, 99%, Thermo Scientific Chemicals
SKU: ALFB22146.06

CAS: 329-98-6 | C7H7FO2S | 174.189 g/mol

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Specifications

Chemical Name or Materialalpha-Toluenesulfonyl fluoride

CAS329-98-6

Health Hazard 1H301-H314

Health Hazard 2GHS H Statement
H301-H314-H318
Toxic if swallowed.
Causes severe skin burns and eye damage.
Causes serious eye damage.

Health Hazard 3P260-P264b-P270-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

α-Toluenesulfonyl fluoride (PMSF) is used in the preparation of cell lysates to inhibit protein digestion. It is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
α-Toluenesulfonyl fluoride (PMSF) is used in the preparation of cell lysates to inhibit protein digestion. It is a widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity.

Solubility
Soluble in ether, benzene, anhydrous ethanol, methanol, 2- propane. Hydrolyses in water.

Notes
Moisture sensitive. Store away from strong oxidizing agents, amines, bases, water/ moisture. Store at 4°C

RUO – Research Use Only

General References:

C Pinsky; A K Dua; F S LaBella. Phenylmethylsulfonyl fluoride (PMSF) given systemically produces naloxone-reversible analgesia and potentiates effects of beta-endorphin given centrally. Life Sciences. 1982, 31 (12-13), 1193-1196.
G T James.Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers. Analytical Biochemistry. 1978, 86 (2), 574-579.