2-Aminoethyl diphenylborinate, 98%, Thermo Scientific Chemicals
Element SearchElement SearchStructure SearchStructure Search
2-Aminoethyl diphenylborinate, 98%, Thermo Scientific Chemicals
2-Aminoethyl diphenylborinate, 98%, Thermo Scientific Chemicals
2-Aminoethyl diphenylborinate, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

2-Aminoethyl diphenylborinate, 98%, Thermo Scientific Chemicals

CAS: 524-95-8 | C14H16BNO | 225.10 g/mol
Have Questions?
Catalog NumberQuantity
ALFA16606.065 g
Catalog number ALFA16606.06
View Price:Sign in to see your account pricing. Need an account? Register with us today.
Quantity:
5 g
Request bulk or custom format
Chemical Identifiers
CAS5334-39-4
IUPAC Name5-methyl-4-nitro-1H-pyrazole
Molecular FormulaC4H5N3O2
InChI KeyWTZYTQJELOHMMJ-UHFFFAOYSA-N
SMILESCC1=C(C=NN1)[N+]([O-])=O
View more
SpecificationsSpecification SheetSpecification Sheet
Melting Point (clear melt)129.0-139.0?C
Assay (GC)≥96.0%
FormCrystals or powder or crystalline powder
Appearance (Color)White to pale cream to cream to yellow
2-Aminoethyl diphenylborinate is used for the densitometric determination of flavonoids and TRP activator. It is also used to manipulate intracellular release of calcium ions and in preparation of apoptotic inducers. It serves as a reactant for preparation of apoptotic inducers and in membrane-permeable SOCE (store operated calcuym entry) inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2-Aminoethyl diphenylborinate is used for the densitometric determination of flavonoids and TRP activator. It is also used to manipulate intracellular release of calcium ions and in preparation of apoptotic inducers. It serves as a reactant for preparation of apoptotic inducers and in membrane-permeable SOCE (store operated calcuym entry) inhibitor.

Solubility
Soluble in ethanol and methanol.

Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Reagent for densitometric determination of flavonoids: J. Chromat., 351, 351 (1986); 437, 260 (1988).
  2. Ozaki, S.; Suzuki, A. Z.; Bauer, P. O.; Ebisui, E.; Mikoshiba, K. 2-Aminoethyl diphenylborinate (2-APB) analogues: Regulation of Ca2+ signaling. Biochem. Biophys. Res. Commun. 2013, 441 (2), 286-290.
  3. Hofer, A.; Kovacs, G.; Zappatini, A.; Leuenberger, M.; Hediger, M. A.; Lochner, M. Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioinorg. Med. Chem. 2013, 21 (11), 3202-3213.
  4. Yildar, M.; Aksit, H.; Korkut, O.; Ozyigit, M. O.; Sunay, B.; Seyrek, K. Protective effect of 2-aminoethyl diphenylborinate on acute ischemia-reperfusion injury in the rat kidney. J. Surg. Res. 2014, 187 (2), 683-689.
  5. Mossaad, E.; Furuyam, W.; Enomoto,M.; Kawai, S.; Mikoshibaf, K.; Kawazu, S. Simultaneous Administration of 2-Aminoethyl Diphenylborinate and Chloroquine Reverses Chloroquine Resistance in Malaria Parasites. Antimicrob. Agents Chemother. 2015,59 (5), 2890-2892.
  6. Agatonovic-Kustrin, S.; Hettiarachchi, C. G.; Morton, D. W.; Razic, S. Analysis of phenolics in wine by high performance thin-layer chromatography with gradient elution and high resolution plate imaging. J. Pharm. Biomed. Anal. 2015, 102, 93-99.