Maleic acid, 98+%, Thermo Scientific Chemicals
Maleic acid, 98+%, Thermo Scientific Chemicals
Maleic acid, 98+%, Thermo Scientific Chemicals
Maleic acid, 98+%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Maleic acid, 98+%, Thermo Scientific Chemicals

CAS: 110-16-7 | C4H4O4 | 116.07 g/mol
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250 g
5000 g
Catalog number ALFA14596.30
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Specifications
Chemical Name or MaterialMaleic acid
CAS110-16-7
Melting Point132°C to 136°C
Health Hazard 1H302+H312-H314-H317-H335
Health Hazard 2GHS H Statement
H302-H315-H319-H317-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause an allergic skin reaction.
May cause respiratory irritation.
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Maleic acid is used as a precursor to fumaric acid, dimethyl maleate and glyoxalic acid. It is an electrophile and acts as dienophine in Diels-Alder reactions. It reacts with drugs to form more stable addition salts like indacaterol maleate, carfenazine, chlorpheniramine, pyrilamine, methylergonovine and thiethylperazine. Its maleate ion is useful in biochemistry as an inhibitor of transaminase reactions.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Maleic acid is used as a precursor to fumaric acid, dimethyl maleate and glyoxalic acid. It is an electrophile and acts as dienophine in Diels-Alder reactions. It reacts with drugs to form more stable addition salts like indacaterol maleate, carfenazine, chlorpheniramine, pyrilamine, methylergonovine and thiethylperazine. Its maleate ion is useful in biochemistry as an inhibitor of transaminase reactions.

Solubility
Soluble in water, acetone, glacial acetic acid, alcohol and concentrated sulfuric acid. Slightly soluble in diethyl ether. Insoluble in benzene and chloroform.

Notes
Incompatible with oxidizing agents, bases, reducing agents, metals and alkalis.
RUO – Research Use Only

General References:

  1. Tsukigawa, K.; Liao, L.; Nakamura, H.; Fang, J.; Greish, K.; Otagiri, M.; Maeda, H. Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin. Cancer Sci. 2015, 106 (3), 270-278.
  2. Filippov, A.; Tarabukina, E.; Simonova, M.; Kirila, T.; Fundueanu, G.; Harabagiu, V.; Constantin, M.; Popescu, I. Synthesis and Investigation of Double Stimuli-Responsive Behavior of N-Isopropylacrylamide and Maleic Acid Copolymer in Solutions. J. Macromol. Sci. Part B Phys. 2015, 54 (9), 1105-1121.