4-Nitrophenol, 99%, Thermo Scientific Chemicals
Element SearchElement SearchStructure SearchStructure Search
4-Nitrophenol, 99%, Thermo Scientific Chemicals
4-Nitrophenol, 99%, Thermo Scientific Chemicals
4-Nitrophenol, 99%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

4-Nitrophenol, 99%, Thermo Scientific Chemicals

CAS: 100-02-7 | C6H5NO3 | 139.11 g/mol
Have Questions?
Change viewbuttonViewtableView
Quantity:
1000 g
250 g
Catalog number ALFA14376.0B
View Price:Sign in to see your account pricing. Need an account? Register with us today.
Quantity:
1000 g
Request bulk or custom format
Chemical Identifiers
CAS39512-49-7
IUPAC Namehydrogen 4-(4-chlorophenyl)piperidin-4-ol chloride
Molecular FormulaC11H15Cl2NO
InChI KeyPXAJMBHRLGKPQV-UHFFFAOYSA-N
SMILES[H+].[Cl-].OC1(CCNCC1)C1=CC=C(Cl)C=C1
View more
SpecificationsSpecification SheetSpecification Sheet
Loss on drying=<0.5 % (1 g, 105°C, 2 h, 760 mmHg)
Sulfated ash=<0.2 %
UV(1 % w/v in DMF) 1 cm silica cell
Appearance (Color)White to cream
Appearance (Form)Crystalline powder
View more
4-Nitrophenol is used as a precursor to prepare phenetidine, acetophenetidne and pH indicator. Its carboxylate ester derivatives are involved as an active component for the construction of amide moieties in peptide synthesis. It is used as an intermediate in the synthesis of paracetamol and N-acetyl-p-aminophenol dyestuffs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Nitrophenol is used as a precursor to prepare phenetidine, acetophenetidne and pH indicator. Its carboxylate ester derivatives are involved as an active component for the construction of amide moieties in peptide synthesis. It is used as an intermediate in the synthesis of paracetamol and N-acetyl-p-aminophenol dyestuffs.

Solubility
Freely soluble in alcohol, chloroform, ether. Freely soluble in acetone. Slightly soluble in water.

Notes
Incompatible with strong oxidizing agents and strong bases.
RUO – Research Use Only

General References:

  1. Acid-base indicator: pH 5.6 - 7.6.
  2. Forms active esters with N-protected amino acids, useful in peptide synthesis; see, for example: J. Org. Chem., 62, 1356 (1997). For peptide reagents, see Appendix 6.
  3. Suzuki-type coupling of the triflate with various arylboronic acids gives biaryl derivatives: Tetrahedron, 45, 6679 (1984). For an example of Stille coupling of the triflate with an arylstannane, catalyzed by trans-Dichlorobis(triphenyl phosphine) palladium(II) , 10491, see: Org. Synth. Coll., 9, 553 (1998).
  4. Ye, W.; Yu, J.; Zhou, Y.; Gao, D.; Wang, D.; Wang, C.; Xue, D. Green synthesis of Pt-Au dendrimer-like nanoparticles supported on polydopamine-functionalized graphene and their high performance toward 4- nitrophenol reduction. Appl. Catal., B 2015, 181, 371-378.
  5. Chaudhary, S.; Kumar, S.; Mehta, S. K. Glycol modified gadolinium oxide nanoparticles as a potential template for selective and sensitive detection of 4-nitrophenol. J. Mater. Chem. C 2015, 3 (34), 8824-8833.