Guanidine hydrochloride, 98%, Thermo Scientific Chemicals

Name: Guanidine hydrochloride, 98%, Thermo Scientific Chemicals
SKU: ALFA13543.0B

Guanidine hydrochloride, CAS # 50-01-1, is an ionic buffer component used for nucleic acids (DNA and RNA) and protein isolation.

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250 g

Catalog number ALFA13543.0B

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Chemical Identifiers

CAS1941-27-1

IUPAC Nametetrabutylazanium nitrate

Molecular FormulaC16H36N2O3

InChI KeyQHOKENWFMZXSEU-UHFFFAOYSA-N

SMILES[O-][N+]([O-])=O.CCCC[N+](CCCC)(CCCC)CCCC

Specifications

Specification Sheet

Appearance (Color)White

Infrared spectrumConforms

Titration with HClO4>=97.5 %

Appearance (Form)Crystalline powder

Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Guanidine hydrochloride is the hydrochloride salt of guanidine, an acetylcholine releasing agent
It is a normal product of protein metabolism and is sometimes used for pyrimidine synthesis

Application

Guanidine hydrochloride is a powerful denaturant, useful for taking nucleic acids (DNA and RNA) and proteins out of their native conformation
Guanidine hydrochloride acts as a strong organic base at physiological pH
It is suitable for use in protein and nucleic acid purification protocols

RUO – Research Use Only

General References:

Tihonov, M. M.; Milyaeva, O. Y.; Noskov, B. A. Dynamic surface properties of lysozyme solutions. Impact of urea and guanidine hydrochloride. Colloids Surf., B 2015, 129, 114-120.
Mikhail M. T.; Akentiev, A. V.; Noskov, B. A. Influence of guanidine hydrochloride and urea on the dynamic surface properties of lysozyme solutions. Mendeleev Commun 2015, 25 (4), 288-289.