N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%, Thermo Scientific Chemicals
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N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%, Thermo Scientific Chemicals
N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%, Thermo Scientific Chemicals
N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%, Thermo Scientific Chemicals

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Catalog number ALFA12033.09
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Chemical Identifiers
CAS7758-99-8
IUPAC Namecopper(2+) pentahydrate sulfate
Molecular FormulaCuH10O9S
InChI KeyJZCCFEFSEZPSOG-UHFFFAOYSA-L
SMILESO.O.O.O.O.[Cu++].[O-]S([O-])(=O)=O
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SpecificationsSpecification SheetSpecification Sheet
Total nitrogen (as N)=<0.002 %
Lead (Pb)=<50 ppm
Appearance (Form)Crystalline powder or crystals
Chloride (Cl)=<10 ppm
Nickel (Ni)=<20 ppm
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N,O-Bis(trimethylsilyl)trifluoroacetamide is used as a derivatization reagent for gas chromatography and mass-spectrometry analysis of phenolic acids in fruits. It is also used as a reactant in the preparation of pyrimidinone ribosides and analogs which shows anti-tumor properties. It plays as an important role as a reagent for the regioselective desulfation of polysaccharide sulfates. Furthermore, it is used to prepare trimethylsilyl ethers of carbohydrates and alcohols.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N,O-Bis(trimethylsilyl)trifluoroacetamide is used as a derivatization reagent for gas chromatography and mass-spectrometry analysis of phenolic acids in fruits. It is also used as a reactant in the preparation of pyrimidinone ribosides and analogs which shows anti-tumor properties. It plays as an important role as a reagent for the regioselective desulfation of polysaccharide sulfates. Furthermore, it is used to prepare trimethylsilyl ethers of carbohydrates and alcohols.

Solubility
Miscible with chloroform.

Notes
Moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place Incompatible with strong oxidizing agents and strong acids.
RUO – Research Use Only

General References:

  1. Powerful silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions, similar to N,O-Bis(trimethyl silyl) acetamide, L00183, with the advantage that both the reagent and its by-product, trifluoroacetamide, are more volatile than the corresponding non-fluorinated analogues: Biochem. Biophys. Res. Commun., 31, 616 (1968). See Appendix 4.
  2. Sagona, J. A.; Dukett, J. E.; Hawley, H. A.; Mazurek, M. A. Sequential derivatization of polar organic compounds in cloud water using O-(2, 3, 4, 5, 6-pentafluorobenzyl) hydroxylamine hydrochloride, N, O-bis (trimethylsilyl) trifluoroacetamide, and gas-chromatography/mass spectrometry analysis. J. Chromatogr. A 2014, 1362, 16-24.
  3. Irei, S.; Rudolph, J.; Huang, L. Compound-specific stable carbon isotope ratios of phenols and nitrophenols derivatized with N, O-bis (trimethylsilyl) trifluoroacetamide. Anal. Chim. Acta 2013, 786, 95-102.