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Tetra-n-butylphosphonium bromide, 99%, Thermo Scientific Chemicals
CAS: 3115-68-2 | C16H36BrP | 339.342 g/mol
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Catalog number ALFA10868.14
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Quantity:
25 g
Specifications
Chemical Name or MaterialTetra-n-butylphosphonium bromide
CAS3115-68-2
Health Hazard 1Danger
Health Hazard 2GHS H Statement
H310-H318-H302-H332-H315-H335
Fatal in contact with skin.
Causes serious eye damage.
Harmful if swallowed.
Harmful if inhaled.
Causes skin irritation.
May cause respiratory irritation.
H310-H318-H302-H332-H315-H335
Fatal in contact with skin.
Causes serious eye damage.
Harmful if swallowed.
Harmful if inhaled.
Causes skin irritation.
May cause respiratory irritation.
Health Hazard 3GHS P Statement
P261-P305+P351+P338-P361-P302+P350-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
Remove/Take off immediately all contaminated clothing.
IF ON SKIN: Gently wash with plenty of soap and water.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
P261-P305+P351+P338-P361-P302+P350-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
Remove/Take off immediately all contaminated clothing.
IF ON SKIN: Gently wash with plenty of soap and water.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
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Tetra-n-butylphosphonium bromide is used as a phase-transfer catalyst at high temperatures, at which nitrogen analogues tend to undergo elimination e.g. as catalyst for the dealkoxycarbonylation of malonates and β-keto esters by heating in stearic acid. used as an ionic liquid solvent in the regioselective O-alkylation of C/O ambident nucleophiles. It is a synthetic reagent used in proteomics research.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Tetra-n-butylphosphonium bromide is used as a phase-transfer catalyst at high temperatures, at which nitrogen analogues tend to undergo elimination e.g. as catalyst for the dealkoxycarbonylation of malonates and ß-keto esters by heating in stearic acid. used as an ionic liquid solvent in the regioselective O-alkylation of C/O ambident nucleophiles. It is a synthetic reagent used in proteomics research.
Solubility
Soluble in water (70 g/100 ml)
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. It is hygroscopic in nature.
Tetra-n-butylphosphonium bromide is used as a phase-transfer catalyst at high temperatures, at which nitrogen analogues tend to undergo elimination e.g. as catalyst for the dealkoxycarbonylation of malonates and ß-keto esters by heating in stearic acid. used as an ionic liquid solvent in the regioselective O-alkylation of C/O ambident nucleophiles. It is a synthetic reagent used in proteomics research.
Solubility
Soluble in water (70 g/100 ml)
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. It is hygroscopic in nature.
RUO – Research Use Only
General References:
- Pascal Claina.; Anthony Delahayea.; Laurence Fournaisona.; Nadia Mayoufib.; Didier Dalmazzoneb.; Walter Fürstb. Rheological properties of tetra-n-butylphosphonium bromide hydrate slurry flow. Tetrahedron Letters. 1992, 193-194, 112-122.
- Rena M. Pomaville.; Salwa K. Poole.; LaDonna J. Davis.; Colin F. Poole. Solute—solvent interactions in tetra-n-butylphosphonium salts studied by gas chromatography. Chemical Engineering Journal. 1988, 438, 1-14.
- Quaternary phosphonium salt, useful as a phase-transfer catalyst at high temperatures, at which nitrogen analogues tend to undergo elimination (see Appendix 2), e.g. as catalyst for the dealkoxycarbonylation of malonates and ß-keto esters by heating in stearic acid: Synthesis, 320 (1985).
- Has been used as an ionic liquid solvent in the regioselective O-alkylation of C/O ambident nucleophiles: Tetrahedron Lett., 33, 4435 (1992); see Tetra-n-butyl ammonium bromide, A10249.