Indomethacin

Name: Indomethacin
SKU: ACR458030050

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID).

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Catalog number ACR458030050

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Chemical Identifiers

CAS140-10-3

IUPAC Name(2E)-3-phenylprop-2-enoic acid

Molecular FormulaC9H8O2

InChI KeyWBYWAXJHAXSJNI-VOTSOKGWSA-N

SMILESOC(=O)\C=C\C1=CC=CC=C1

Specifications

Specification Sheet

Infrared spectrumConforms

Titration with NaOH>=98.0 %

Appearance (Color)White to light yellow

Melting point131°C to 136°C

Appearance (Form)Crystalline powder

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release

• Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics

• Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

• Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions

• Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin

RUO – Research Use Only

General References:

Mitra, S.; Florez, I.D.; Tamayo, M.E.; Mbuagbaw, L.; Vanniyasingam, T.; Veroniki, A.A.; Zea, A.M.; Zhang, Y.; Sadeghirad, B.; Thabane, L. Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. JAMA. 2018, 319(12), 1221-1238.
El-Mashad, A.E.; El-Mahdy, H.; El Amrousy, D.; Elgendy, M. Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. Eur J Pediatr. 2017, 176(2), 233-240.