Finasteride, 98%
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Finasteride, 98%
Finasteride, 98%
Finasteride, 98%
Thermo Scientific Chemicals

Finasteride, 98%

Finasteride, CAS # 98319-26-7, is a 5α-reductase inhibitor that blocks conversion of testosterone and inhibits neurosteroid production.
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Quantity:
1 g
Catalog number ACR458000010
Price (MYR)
1,469.00
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Quantity:
1 g
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Price (MYR)
1,469.00
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Chemical Identifiers
CAS5794-88-7
IUPAC Name2-amino-5-bromobenzoic acid
Molecular FormulaC7H6BrNO2
InChI KeyCUKXRHLWPSBCTI-UHFFFAOYSA-N
SMILESNC1=CC=C(Br)C=C1C(O)=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)Pale cream to cream to pale brown
FormPowder or lumps
Assay (Aqueous acid-base Titration)≥97.5 to ≤102.5%
Assay (HPLC)≥97.5%
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Finasteride is an inhibitor of the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT)
  • Finasteride also has been explored in neuroscience, as 5α-reductase enzymes are present in the central nervous system
  • Finasteride has been seen to cross the blood-brain barrier and block production of neurosteroids

Applications

  • Finasteride is mainly used in studies of prostate hyperplasia and tumors in mice, and can be studied in vitro or in vivo for its effects on hyperplasia, proliferation, and antioxidant activity
  • Its activity has also been explored in brain, liver and testis tissues
  • In vivo injection of finasteride has been shown to decrease neurogenesis and influence neuronal plasticity in mice
RUO – Research Use Only

General References:

  1. Kim, H.J.; Kim, T.J.; Kim, Y.G.; Seong, C.; Cho, J.H.; Kim, W.; Lee, K.H.; Kim, D.Y. Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells. Pharmaceutics. 2021, 13(9), 1410.
  2. Chhipa, R.R.; Halim, D.; Cheng, J.; Zhang, H.Y.; Mohler, J.L.; Ip, C.; Wu, Y. The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific. Prostate. 2013, 73(14), 1483-94.
  3. Römer, B.; Pfeiffer, N.; Lewicka, S.; Ben-Abdallah, N.; Vogt, M.A.; Deuschle, M.; Vollmayr, B.; Gass, P. Finasteride treatment inhibits adult hippocampal neurogenesis in male mice. Pharmacopsychiatry. 20100, 43(5), 174-8.