Diclofenac sodium, 98%

Diclofenac sodium, CAS # 15307-79-6, is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis.

Catalog Number	Quantity	Packaging
ACR445250100	10 g	Glass bottle

Catalog number ACR445250100

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Glass bottle

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Specifications

Chemical Name or MaterialDiclofenac sodium

CAS15307-79-6

Health Hazard 1GHS Signal Word: Danger

Health Hazard 2GHS H Statement
Toxic if swallowed.

Health Hazard 3GHS P Statement
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Diclofenac is a is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties
Diclofenac has been shown to have anti-tumor capabilities through inhibition of MYC expression and glucose metabolism in models of melanoma and leukemia

Applications

Diclofenac sodium can be used as an antioxidant and free radical scavenger
It has been shown to have anti-bacterial activity against Listeria, E. coli, and M. tuberculosis partially through inhibition of bacterial DNA synthesis
It can be used for the study of metabolic activity as a CYP2C9 substrate

RUO – Research Use Only

General References:

Altman, R; Bosch, B.; Brune, K.; Patrignani, P.; Young, C. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015, 75(8), 859-77.
Tang, Y.Z.; Liu, Z.Q. Evaluation of the free-radical-scavenging activity of diclofenac acid on the free-radical-induced haemolysis of human erythrocytes. J Pharm Pharmacol. 2006, 58(5), 625-31.
Mazumdar K, Dastidar SG, Park JH, Dutta NK. The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target. Eur J Clin Microbiol Infect Dis. 2009, 28(8), 881-91.
Gottfried, E.; Lang, S.A.; Renner, K.; Bosserhoff, A.; Gronwald, W.; Rehli, M.; Einhell, S.; Gedig, I.; Singer, K.; Seilbeck, A.; Mackensen, A.; Grauer, O.; Hau, P.; Dettmer, K.; Andreesen, R.; Oefner, P.J.; Kreutz, M. New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells. PLoS One. 2013, 8(7), e66987.
Feng, S.; Wu, J.; Qiu, W.L.; Yang, L.; Deng, X.; Zhou, Y.; Chen, Y.; Li, X.; Yu, L.; Li, H.; Xu, Z.R.; Xiao, Y.; Ren, X.; Zhang, L.; Wang, C.; Sun, Z.; Wang, J.; Ding, X.; Chen, Y.; Gadue, P.; Pan, G.; Ogawa, M.; Ogawa S, Na J, Zhang P, Hui L, Yin H, Chen L, Xu CR, Cheng X. Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells. Cell Rep. 2020, 33(10), 108455.
Cantoni, L.; Valaperta, R.; Ponsoda, X.; Castell, J.V.; Barelli, D., Rizzardini, M.; Mangolini, A.; Hauri, L.; Villa, P. Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity. J Hepatol. 2003, 38(6), 776-83.