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Fumonisin B1, 96%, Thermo Scientific Chemicals
Fumonisin, CAS # 116355-83-0, also known as Macrofusine, is a cell permeable mycotoxin that is an inhibitor of sphingosine N-acetyl transferase.
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Catalog number ACR328250050
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Quantity:
5 mg
Specifications
Chemical Name or MaterialFumonisin B1
CAS116355-83-0
Health Hazard 1GHS Signal Word: Warning
Health Hazard 2GHS H Statement:
Suspected of causing cancer.
Suspected of causing cancer.
Health Hazard 3GHS P Statement:
Use personal protective equipment as required.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
Use personal protective equipment as required.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Fumonisin is a fungal metabolite that is a cell permeable mycotoxin that can halt sphingolipid biosynthesis by inhibiting sphingosine N-acetyl transferase
Applications
• It can potently inhibit sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases
• It is also a protein serine and threonine phosphatase inhibitor
• It can selectively inhibit sphingomyelin biosynthesis in neuronal cells
RUO – Research Use Only
General References:
- Stockmann-Juvala, H., et al., 2008. A review of the toxic effects and mechanisms of action of fumonisin B1. Human & experimental toxicology. 27(11), 799-809.
- Fukuda et al (1996) Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin. Biochem.Biophys.Res.Comms. 220 160.