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L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals
L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity.
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Catalog number ACR208101000
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Quantity:
100 mg
Packaging:
Glass Bottle
Specifications
Chemical Name or MaterialL(+)-Amethopterin hydrate
CAS133073-73-1
Health Hazard 1GHS Signal Word: Danger
Health Hazard 2GHS H Statement:
Toxic if swallowed.
May cause genetic defects.
May damage the unborn child.
Toxic if swallowed.
May cause genetic defects.
May damage the unborn child.
Health Hazard 3GHS P Statement:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
- It has tumoricidal activity
Applications
- L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
- It can be used in anti-tumor studies
- It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
- It can also inhibit production of pro-inflammatory cytokines
RUO – Research Use Only
General References:
- Friedman, B.; Cronstein, B. Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine. 2019, 86(3), 301-307.
- Sasso, S.P.; Gilli, R.M.; Sari, J.C.; Rimet, O.S.; Briand, C.M. Thermodynamic study of dihydrofolate reductase inhibitor selectivity. Biochim Biophys Acta. 1994, 20, 1207(1), 74-9.
- Pittman, S.M.; Strickland, D.; Ireland, C.M. Polymerization of tubulin in apoptotic cells is not cell cycle dependent. Exp Cell Res. 1994, 215 (2), 263-72.