2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals
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2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals
2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals
2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals

2-Mercapto-1-methylimidazole, CAS # 60-56-0, also known as methimazole, is a thyroid hormone antagonist used to study the treatment of thyroid disorders.
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Quantity:
100 g
25 g
Packaging:
Glass bottle
Catalog number ACR125501000
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Quantity:
100 g
Packaging:
Glass bottle
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Specifications
Chemical Name or Material2-Mercapto-1-methylimidazole
CAS60-56-0
Health Hazard 1GHS Signal Word: Warning
Health Hazard 2GHS H Statement
May cause an allergic skin reaction.
Suspected of damaging fertility.
Suspected of damaging the unborn child.
Health Hazard 3GHS P Statement
Wear eye protection/face protection.
Use personal protective equipment as required.
Avoid breathing dust/fume/gas/mist/vapors/spray.
Contaminated work clothing should not be allowed out of the workplace.
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • 2-Mercapto-1-methylimidazole, also known as methimazole, is an antithyroid medication
  • Methimazole works by inhibiting the enzyme thyroid peroxidase (TPO), which is responsible for synthesizing the thyroid hormones triiodothyronine (T3) and thyroxine (T4) from the precursor thyroglobulin

Applications

  • Methimazole has been used in laboratory settings to model olfactory epithelial degeneration
  • May be used to study disruptions in iodide metabolism
  • Methimazole has been used in Pharmacokinetics studies in the laboratory
RUO – Research Use Only

General References:

  1. Stanley, M.M.; Astwood, E.B. 1-Methyl-2-mercaptoimidazole; an antithyroid compound highly active in man. Endocrinology. 1949, 44(6), 588.
  2. Ogawa, T.; Takezawa, K.; Shimizu, S.; Shimizu, T. Valproic acid promotes neural regeneration of olfactory epithelium in adult mice after methimazole-induced damage. Am J Rhinol Allergy. 2014, 28(2), e95-9.
  3. Furman, B.L. in xPharm: The Comprehensive Pharmacology Reference. Methimazole. 2007 pp 1-4.